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Baines Receives NHLBI Grant to Study Cardiac Disease

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The National Heart, Lung, and Blood Institute at the National Institutes of Health recently awarded Chris Baines, PhD, a five-year, $1,865,250 grant. Baines is an assistant professor of biomedical sciences at the MU College of Veterinary Medicine and an investigator at the Dalton Cardiovascular Research Center.

Baines’ research studies proteins that regulate an entity known at the mitochondrial permeability transition pore. Opening of this pore causes mitochondrial dysfunction and ultimately cell death, and it has been shown to lead to cardiac disease.

The grant-funded research will study a negative regulator of the mitochondrial pore called C1qbp and a positive regulator called GSK3b and how they modulate cardiac cell death, both in cultured cells and in genetically modified mice.

“By understanding the proteins that regulate the mitochondrial pore, and the mechanisms by which they do so, therapeutic agents can be developed that target these proteins for the treatment of cardiac disease in patients,” Baines said.

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Graduate Studies in Biomedical Sciences

At the Department of Biomedical Sciences, investigators are engaged in research across a variety of fields, including cancer, neurodegenerative disease, exercise, cardiovascular, gastrointestinal, respiratory and reproductive physiology.

With world-class and award-winning researchers, our graduate program has a great deal to offer.

Find out more.

Faculty Spotlight

Xiangwei (Shaun) Du, PhD

News

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  • Retired Associate Dean Ronald L. Terjung Passes Away

Contact

Department of Biomedical Sciences
University of Missouri-Columbia
E102 Veterinary Medical Building
1520 Rollins Street
Columbia, MO 65211
Phone: 573-882-7011
Fax: 573-884-6890

 

Administrative Contacts

Dr. Douglas Bowles
Department Chair

BowlesD@missouri.edu
573-882-7193

Dr. Kevin Cummings
Director of Graduate Studies
cummingske@missouri.edu
573-882-0283

Thomas Thompson
Business Manager

ThompsonT@missouri.edu
573-882-4503

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