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Mucus is Retained in Cystic Fibrosis Patients’ Cells, Leads to Potentially Deadly Infections

Finding could lead to treatments for cystic fibrosis


Cystic fibrosis is a genetic disorder that affects one out of every 3,000 children in populations of Northern European descent. One of the key signs of cystic fibrosis is that mucus lining the lungs, pancreas and other organs is too sticky, which makes it difficult for the organs to work properly and, in the lungs, attracts bacteria and viruses resulting in chronic infections. Researchers at the University of Missouri recently found that cystic fibrosis mucus actually gets stuck inside some of the cells that create it, rather than simply becoming stuck on the outside linings of organs.

Lane Clarke, a professor of biomedical sciences in the MU College of Veterinary Medicine, says that now that it is better understood how mucus becomes trapped in the body, scientists can begin working on potential treatments for patients with cystic fibrosis that help cells remove the sticky mucus more quickly.

“Normally, special cells create mucus and easily push it out to the linings of the organs where it belongs,” said Clarke, who also is a Dalton Investigator in the MU Dalton Cardiovascular Research Center. “However, in cystic fibrosis patients, some cells that create the mucus fail to completely release the mucus, so the mucus becomes stuck halfway in and halfway out.  This makes mucus clearance more difficult and potentially would allow bacteria to have an easy pathway to infecting cells to cause diseases like pneumonia.”

Clarke also examined the characteristics of mucus stored within the cells and found that it is not as acidic as in normal cells.

“Previously, cystic fibrosis researchers disagreed as to whether cystic fibrosis cells also have a defect in properly acidifying areas inside cells,” Clarke said. “Finding that cystic fibrosis mucus granules are not acidic is important because the lack of acidity slows the release of products from other secreting cells.  Knowing this will allow us to begin further investigation into what causes this lack of acidity, which could eventually be another pathway to developing treatments for this disease.”

This study was published in the Journal of Clinical Investigation.

MU News Bureau: https://nbsubscribe.missouri.edu/news-releases/2015/0218-mucus-is-retained-in-cystic-fibrosis-patients%e2%80%99-cells-leads-to-potentially-deadly-infections/

Graduate Studies in Biomedical Sciences

At the Department of Biomedical Sciences, investigators are engaged in research across a variety of fields, including cancer, neurodegenerative disease, exercise, cardiovascular, gastrointestinal, respiratory and reproductive physiology.

With world-class and award-winning researchers, our graduate program has a great deal to offer.

Find out more.

Faculty Spotlight

Xiangwei (Shaun) Du, PhD

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  • Retired Associate Dean Ronald L. Terjung Passes Away

Contact

Department of Biomedical Sciences
University of Missouri-Columbia
E102 Veterinary Medical Building
1520 Rollins Street
Columbia, MO 65211
Phone: 573-882-7011
Fax: 573-884-6890

 

Administrative Contacts

Dr. Douglas Bowles
Department Chair

BowlesD@missouri.edu
573-882-7193

Dr. Kevin Cummings
Director of Graduate Studies
cummingske@missouri.edu
573-882-0283

Thomas Thompson
Business Manager

ThompsonT@missouri.edu
573-882-4503

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