Bender Receives Grant to Study Mechanisms Underlying Obesity-Associated Cardiovascular Disease

Shawn B. Bender

Shawn B. Bender

The National Heart, Lung, and Blood Institute at the National Institutes of Health recently awarded Shawn Bender, PhD, a five-year, $2.8 million grant. Together with co-investigator Doug Bowles, PhD, professor and chair of Biomedical Sciences, Iris Jaffe, PhD, MD, Tufts University School of Medicine, and Johnathan Tune, PhD, Indiana University, Bender aims to elucidate specific mechanisms underlying obesity-associated cardiovascular disease and thereby identify novel therapeutic targets.

Obesity and the metabolic syndrome have reached epidemic proportions in the United States, impacting more than 60 percent of adults. Cardiovascular diseases, including hypertension, stroke, coronary artery disease, myocardial infarction, congestive heart failure, and sudden cardiac death are the primary causes of morbidity and mortality in these patients.

The results of this research may provide direct rationale for innovative therapeutic interventions to reduce the incidence and impact of coronary and cardiac complications in the ever-increasing population of obese/metabolic syndrome patients.