Department of Biomedical Sciences

University of Missouri

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Chada S. Reddy, B.V.Sc., PhD

  • Associate Professor

Email: ReddyC@missouri.edu

Teaching: Toxicology

Research Interests:

Dr. Reddy’s research focus is on the mechanisms of pathogenesis of developmental defects (especially cleft palate) by mycotoxins (e.g., secalonic acid D) and other chemicals to which human beings and animals are exposed. Dr. Reddy’s interests also include the elucidation of toxic effects of environmental chemicals on animal reproduction.

Cleft Palate is the most common developmental abnormality both in human beings and animals. A mouse model and embryonic palatal mesenchymal cells of mouse and human origin are being utilized to investigate the effect of chemicals on various palatal signaling mechanisms (including those of growth factors and other extracellular ligands) involved in the synthesis of extracellular matrix components, apoptosis and cell proliferation. Effect of chemicals on palatal protein kinases (PKA, PKC and Cyclin Dependent Kinases) and cell cycle genes are the focus of current studies aimed at understanding their roles in normal palate development and in abnormal palate development following chemical exposure. Ultimate goal is to develop gene modulation approaches relevant to the prevention of chemical-induced developmental defects (cleft palate) even in the face of their continuing exposure.

Selected Publications:

Balasubramanian G and Reddy CS: Novel Mechanism of Protein Kinase C Inhibition Involving the Pseudosubstrate Region by Secalonic Acid D. Toxicol Appl Pharmacol, 163: 86-93, 2000.

Balasubramanian G Hanumegowda U and Reddy CS: Secalonic acid D alters the nature and inhibits the binding of the transcription factors to the phorbol 12-O-tetradecanoate-13-acetate (TPA)-response element in the developing murine secondary palate. Toxicol Appl Pharmacol, 169: 142-150, 2000.

Umesh H Balasubramanian G and Reddy CS: Secalonic acid D alters the phosphorylation of transcription factors and their binding to cAMP response element in developing murine secondary palate. J. Craniofac.Genet. Dev. Biol., 20:173-182, 2001.

Hanumegowda U Dhulipala VC and Reddy CS: Mechanism of Secalonic acid D-induced inhibition of transcription factor binding to cyclic AMP response element in developing murine palate, Toxicol Sci, , 70:55-62, 2002.

Dhulipala VC, Hanumegowda UM, Balasubramanian G and Reddy CS: Relevance of the palatal protein kinase A pathway to the pathogenesis of cleft palate by secalonic acid D in mice, Toxicol Appl Pharmacol, 194:270-279, 2004.

Dhulipala, V. C., Welshons, W. V. and Reddy, C. S.: Inhibition of Human Embryonic Palatal Mesenchymal Cell Cycle by Secalonic Acid D: A Probable Mechanism of Its Cleft Palate Induction, Orthodont. Craniofac. Res., 7:227-236, 2004.

 

Graduate Studies in Biomedical Sciences

At the Department of Biomedical Sciences, investigators are engaged in research across a variety of fields, including cancer, neurodegenerative disease, exercise, cardiovascular, gastrointestinal, respiratory and reproductive physiology.

With world-class and award-winning researchers, our graduate program has a great deal to offer.

Find out more.

Faculty Spotlight

Xiangwei (Shaun) Du, PhD

News

  • Expertise, Collegiality Earn Tommy Thompson Dean’s Impact Award
  • SEC Emerging Scholars Program Helps Guide Career Options for Biomedical Sciences Fellow
  • Prenatal Opioid Exposure May Trigger Neurological, Behavioral Changes Later in Life
  • Research With Heart
  • Retired Associate Dean Ronald L. Terjung Passes Away

Contact

Department of Biomedical Sciences
University of Missouri-Columbia
E102 Veterinary Medical Building
1520 Rollins Street
Columbia, MO 65211
Phone: 573-882-7011
Fax: 573-884-6890

 

Administrative Contacts

Dr. Douglas Bowles
Department Chair

BowlesD@missouri.edu
573-882-7193

Dr. Kevin Cummings
Director of Graduate Studies
cummingske@missouri.edu
573-882-0283

Thomas Thompson
Business Manager

ThompsonT@missouri.edu
573-882-4503

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