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Laurel A. Grisanti, PhD

Assistant Professor

 

  • PhD:  University of North Dakota
  • Postdoctoral Training:  Temple University

Contact Information:

University of Missouri
College of Veterinary Medicine
W191 Veterinary Medicine
825 E Campus Loop
Columbia, MO 65211

Phone:  573-884-8852
Email:  grisantil@missouri.edu

Research Interests

The focus of my research is to understand the mechanisms that regulate the development and progression of heart failure.  In particular, my research investigates the immunomodulatory role of G protein-coupled receptors, primarily adrenergic receptors, following cardiac injury and as a potential therapeutic target for the treatment of heart disease.  β-adrenergic receptors (βAR) are critical regulators of cardiac function both in the healthy and diseased heart.  Cardiac βAR are differentially expressed with the β1AR subtype being predominantly localized to cardiomyocytes where they are known to regulate contractility.  β2AR are predominate on other cells types including fibroblasts and immune cells.  During heart failure, βAR signaling becomes altered and subtype expression ratios change, leading to detrimental hypertrophy, increased cardiomyocyte apoptosis, fibrosis and cardiac dysfunction.  As a result of this dysregulation in βAR signaling, they are a common therapeutic target for the treatment of heart diseases including myocardial infarction (MI) and heart failure.

Following MI, there is an intense inflammatory response that is critical to for clearing the area of dying cardiomyocytes and extracellular matrix debris and activating remodeling pathways.  It has been known for over 100 years that the sympathetic nervous system can influence immune responses in part through its activation of βAR.  βAR are expressed on virtually all cells of the immune system where they impact cell function in a cell type, activation state and disease dependent manner.  β2AR are the most highly and widely expressed βAR subtype in the immune system where they are known to influence a number of different functions including hematopoiesis, lymphopoiesis, thymopoiesis, lymphocyte homing, immune cell maturation and immune cell function.  Regulation of immune functions by β2AR is thought to contribute to a number of different diseases including autoimmune diseases and wound healing.  However, the manner in which β2AR regulate immune responses is often disease dependent and how β2AR regulation of immune responses influences the pathogenesis and progression of heart failure is completely unknown.  We have identified an important role for β2AR in suppressing early immune responses, which leads to impairments in the hearts ability to remodel following ischemic injury.  Mice that lack β2AR in their immune system have decrease leukocyte infiltration following MI as a result of decreased migratory ability through alterations in the chemokine receptor CCR2.  There are also impairments in egress of immune cells from the spleen.  Ongoing studies are investigating the role of β2AR in regulating specific immune cell populations that impact healing following MI, identifying novel mechanisms through which β2AR are influencing the immune response, the impact of β-blockers on inflammatory responses and novel therapeutic strategies targeting β2AR in the immune system to improve outcome after MI.

Selected Publications

  1. Grisanti LA, Shumacher SM, Tilley DG and Koch WJ (2017) Designer Approaches to GPCR Modulation. JACC Basic Transl Sci. In Press.
  2. Grisanti LA, Traynham CJ, Gao E, Koch WJ and Tilley DG (2016) β2-Adrenergic Receptor-Dependent Chemokine Receptor 2 Expression Regulates Leukocyte Recruitment to the Heart Following Acute Injury. Proc Natl Acad Sci USA; 113:15126-15131.
  3. Grisanti LA, Gumpert AM, Traynham CJ, Gorsky JM, Repas AA, Gao E, Carter RL, Yu D, Calvert JW, Pun Garcia A, Ibanez B, Rabinowitz JE, Koch WJ and Tilley DG (2016) Hematopoietic Expression of β2-Adrenergic Receptors is Critical for Survival Following Myocardial Infarction. Circulation; 134:153-67.
  4. Grisanti LA, Repas AA, Carter RL, Talarico JA, Gold JL, Koch WJ and Tilley DG. 2014. Temporal Regulation of Cardiac Cytokine Expression in Response to Chronic β-Adrenergic Receptor Stimulation. Am J Physiol Heart; 38:316-30.
  5. Grisanti LA, Talarico JA, Carter RL, Yu JE, Repas AA, Radcliffe SW, Tang H, Makarewich CA, Houser SR and Tilley DG (2014) β-Adrenergic Receptor-Mediated Transactivation of Epidermal Growth Factor Receptor Decreases Cardiomyocyte Apoptosis Through Differential Subcellular Activation of ERK1/2 and Akt; J Mol Cell Cardiol. 72:39-51.
  6. Grisanti LA, Perez DM and Porter JE. Modulation of Immune Cell Function by α1-Adrenergic Receptor Activation. Curr Top Membr 2011; 67:113-38.
  7. Grisanti LA, Woster AP, Dahlman J, Sauter ER, Combs CK and Porter JE (2010) α1-Adrenergic Receptors Positively Regulate Toll-like Receptor Cytokine Production from Human Monocytes and Macrophages; J Pharmacol Exp Therap. 338(2):648-57.
  8. Grisanti LA, Evanson J, Marchus E, Jorissen H, Woster AP, DeKrey W, Sauter ER, Combs CK and Porter JE (2010) Pro-Inflammatory Responses in Human Monocytes are β1-Adrenergic Receptor Subtype Dependent; Mol Immunol. 47(6):1244-54.

Complete Publication List: http://www.ncbi.nlm.nih.gov/sites/myncbi/10qDjhwr5tkQs/bibliograpahy/49265910/public/?sort=date&direction=ascending

Graduate Studies in Biomedical Sciences

At the Department of Biomedical Sciences, investigators are engaged in research across a variety of fields, including cancer, neurodegenerative disease, exercise, cardiovascular, gastrointestinal, respiratory and reproductive physiology.

With world-class and award-winning researchers, our graduate program has a great deal to offer.

Find out more.

Faculty Spotlight

Xiangwei (Shaun) Du, PhD

News

  • Expertise, Collegiality Earn Tommy Thompson Dean’s Impact Award
  • SEC Emerging Scholars Program Helps Guide Career Options for Biomedical Sciences Fellow
  • Prenatal Opioid Exposure May Trigger Neurological, Behavioral Changes Later in Life
  • Research With Heart
  • Retired Associate Dean Ronald L. Terjung Passes Away

Contact

Department of Biomedical Sciences
University of Missouri-Columbia
E102 Veterinary Medical Building
1520 Rollins Street
Columbia, MO 65211
Phone: 573-882-7011
Fax: 573-884-6890

 

Administrative Contacts

Dr. Douglas Bowles
Department Chair

BowlesD@missouri.edu
573-882-7193

Dr. Kevin Cummings
Director of Graduate Studies
cummingske@missouri.edu
573-882-0283

Thomas Thompson
Business Manager

ThompsonT@missouri.edu
573-882-4503

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