Dr. Yang is using a rat model with peripheral arterial insufficiency (a cardiovascular disease commonly seen in the elderly) to study the mechanisms of expanding collateral circulation. The effect of aging process on arteriogenesis (growing of new arteries) and angiogenesis (growing of new capillary) in response to obstruction of a conduit artery are studied. The molecular basis and functional responses of expansion of collateral circulation, induced by physical activity and administration of angiogenic growth factors are assessed, the outcome from this research will provide important information to treat the patients with peripheral arterial insufficiency.
Srivastava, S., R.L Terjung and H.T. YANG. Basic fibroblast growth factor increases collateral blood flow in spontaneously hypertensive rats. Am. J. Physiol. (Heart Circ. 285)H1190-H1197, 2003.
Prior, B.M., P.G. Lloyd, J. Ren, Z. Li, H.T. Yang, H.M. Laughlin, and R.L. Terjung. Ateriogenesis:Role of Nitric Oxide. Endothelium 10:207-216, 2003.
Prior, B.M., H.T. Yang, and R. L. Terjung. What makes vessels grow with exercise training? J. Appl. Physiol. 97:1119-1128, 2004.
Lloyd, P.G., P.M. Prior, H. Li, YANG, H.T., and R.L Terjung. VEGF receptor antagonism blocks arteriogenesis, but only partially inhibits angiogenesis, in skeletal muscle of exercise trained rats. Am. J. Physiol. (Heart Circ. 2xx) in print, 2004.
Prior, B.M., P.G. Lloyd, J. Ren, H. Li, H.T. Yang, H.M. Laughlin, and R.L. Terjung. Time-course of changes in collateral blood flow, and isolated vessel size and gene expression following femoral artery occlusion in the rat. Am. J. Physiol. (Heart Circ. 287)H2434-H2447, 2004.