Xiangwei (Shaun) Du, PhD

Clinical Assistant Professor (Chemistry/Toxicology)

 

• BS: Shaanxi Normal University, Xi’an, China
• PhD: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
• Postdoctoral Fellowship: Iowa State University, Ames, IA

Office: D202 Veterinary Medical Diagnostic Laboratory
Laboratory: D205 Veterinary Medical Diagnostic Laboratory
Phone: (573) 884-9240
Email:  x.du@missouri.edu

 

Research Interests

My research focuses on analytical toxicology and organic synthesis. For toxicology, I work on developing new analytical assays to detect toxins, nutrition, and veterinary drugs as well as isolation, purification, and characterization of their new metabolites. For organic synthesis, I am interested in designing new probes for biosensor and new veterinary drugs.

Current major interests have centered on fungal metabolites (mycotoxins), tall fescue alkaloids, phyto and fungal estrogens, and nutrition (vitamins).

• Mycotoxins:
  • Mycotoxin culture production (aflatoxin, zearalenone, ochratoxin A, fumonisin, T-2 toxin, etc) in large quantities for animal feeding studies.
  • In vitro and in vivo examination of binders for decontaminating of animal feeds containing high levels of mycotoxins.
  • Developing rapid methods for the quantification of mycotoxins by LC-MS/MS in various matrices.
  • Identify new mycotoxin metabolites.

• Fescue alkaloids:
  • Developing rapid methods for the quantification of fescue alkaloids by LC-MS/MS.
  • Identify new alkaloid metabolites.

• Nutrition:
  • Developing rapid methods for the quantification of vitamin A, vitamin E, vitamin K, and vitamin D.

 

Selected Publications

Du, X.; Schrunk, D. E.; Imerman, P. M.; Smith, L.; Francis, K.; Tahara, J.; Tkachenko, A.; Reimschuessel R.; Rumbeiha, W. K. Evaluation of a Diagnostic Method to Quantify Aflatoxins B1 and M1 in Animal Liver by High-Performance Liquid Chromatography with Fluorescence Detection. J. AOAC Int. 2019, 102, 1530-1534.

Du, X.; Schrunk, D. E.; Shao, D. H.; Imerman, P. M.; Wang, C.; Ensley, S. M.; Rumbeiha, W. K. Intra-laboratory Development and Evaluation of a Quantitative Method for Measurement of Aflatoxins B₁, M₁, and Q₁ in Animal Urine by High Performance Liquid Chromatography with Fluorescence Detection. J. Anal. Toxicol. 2017, 41, 698-707.

Zheng, F.; Du, X.; Chou, T. H.; Yu, E.; Robertson, A. P.; Yu, E. W.; VanVeller, B.; Martin, R. J. (S)-5-ethynyl-anabasine, a Novel Compound, is a More Potent Agonist than other Nicotine Alkaloids on the Nematode Asu-ACR-16 Receptor. Int. J. Parasitol Drugs Drug Resist. 2017, 7, 12-22.

Du, X.; Stanley, L. Tandem Alkyne Hydroacylation and Oxo-Michael Addition: Diastereoselective Synthesis of 2,3-Disubstituted Chroman-4-ones and Fluorinated Derivatives. Org. Lett. 2015, 17, 3276-3279. Highlighted by Synfacts 2015, 11, 964.

Du, X.; Gosh, A.; Stanley, L. Enantioselective Synthesis Polycylic Nitrogen        Heterocycles by Rh-Catalyzed Alkene Hydroacylation: Constructing Six-Membered Rings in the Absence of Chelation Assistance. Org. Lett. 2014, 16, 4036-4039. Highlighted by Synfacts 2014, 10, 1052.

Yoo, W.; Capdevila, M.; Du, X.; Kobayashi, S. Base-Mediated Carboxylation of Unprotected Indole Derivatives with Carbon Dioxide. Org. Lett. 2012, 14, 5326-5329. Highlighted by Synfacts 2013, 9, 83.

Du, X.; Chen, H.; Chen, J.; Liu, Y. Highly Efficient Synthesis of Multisubstituted 2-Acyl Furans via PIFA/I2 Mediated Oxidative Cycloisomerization of cis-2-En-4-yn-1-ols. Synlett, 2011, 7, 1010-1014.

Du, X.; Yang, S.; Yang. J.; Liu, Y. Regio- and Stereoselective Construction of Highly Functionalized 3-Benzazepine Skeletons through Ring-Opening Cycloamination Reactions Catalyzed by Gold. Chem. Eur. J. 2011, 17, 4981-4985.

Xie, X.; Du, X.; Chen, Y.; Liu. Y. One-Pot Synthesis of Indole-Fused Scaffolds via Gold-Catalyzed Tandem Annulation Reactions of 1,2-Bis(alkynyl)-2-en-1-ones with Indoles. J. Org. Chem. 2011, 76, 9175-9181.

Du, X.; Xie, X.;Liu, Y. Gold-Catalyzed Cyclization of Alkynylaziridines as An Efficient Approach Toward Functionalized N-Phth Pyrroles. J. Org. Chem. 2010, 75, 510-513.

Du, X.; Song, F.; Lu, Y. Chen, H.; Liu, Y. A General and Efficient Synthesis of Substituted Furans and Dihydrofurans via Gold-Catalyzed Cyclization of (Z)-2-En-4-yn-1-ols. Tetrahedron. 2009, 65, 1839-1845. This methodology has been utilized by Prof. Dr. K.C. Nicolaou and Prof. Dawei Ma to complete total synthesis of Engleri A and Leucosceptroids A and B. (J. Am. Chem. Soc. 2010,132, 8219-8222. and Angew. Chem. Int. Ed. 2015, 54, 1298-1301.)

Lu, Y.; Du, X.; Jia, X.; Liu, Y. Gold-Catalyzed Intermolecular Reactions of (Z)-Enynols with Indoles for the Construction of Dihydrocyclohepta[b]indole Skeletons through a Cascade Friedel–Crafts/Hydroarylation Sequence. Adv. Synth. Catal. 2009, 351, 1517-1522.

Lu, Y.; Fu, X.; Chen, H.; Du, X.; Jia, X.; Liu, Y. An Efficient Domino Approach for the Synthesis of Multisubstituted Pyrroles via Gold/Silver-Catalyzed Amination/Cycloisomerization of (Z)-2-En-4-yn-1-ols. Adv. Synth. Catal. 2009, 351, 129-134. Highlighted by Synfacts 2009, 4, 370.

Du, X.; Chen, H.; Liu, Y. New Synthetic Approach for the Construction of Multi-Substituted 2-Acyl Furans via IBX-Mediated Cascade Oxidation/Cyclization of cis-2-En-4-yn-1-ols. Chem. Eur. J. 2008, 14, 9495-9498.