Department of Biomedical Sciences

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M. Harold Laughlin, PhD

  • Professor

Email: LaughlinM@missouri.edu

573-882-7011
E102 Vet Med Building
University of Missouri
Columbia, MO 65211

PhD—University of Iowa

Research Interests:

Dr. Laughlin focuses his research on cardiovascular effects of exercise. The primary goal is to understand the effects of exercise training on the coronary circulation and skeletal muscle vascular beds. Exercise training produces increases in the capacity of myocardial and skeletal muscle vascular beds to transport oxygen and other nutrients.

The training-induced changes in vascular transport capacity are associated with growth of new capillaries, enlargement of arteries and veins, and alterations in factors that control blood flow in the heart and skeletal muscle. The lab is currently investigating the mechanisms responsible for these changes.

Studies are conducted with: isolated hearts, isolated muscle tissue, single blood vessels and in conscious, chronically instrumented animals during exercise. To allow examination of the relationship among vascular adaptations and the response of the myocytes to training-induced increases in the functional demands of the muscles, the effects of training on biochemical and histological characteristics of the muscles are also measured.

Dr. Laughlin’s research, which is supported by the PPG, evaluates the role of exercise training-induced changes in endothelial phenotype in the protective effects of exercise on atherosclerotic coronary artery disease.

Selected Publications:

Johnson, L. R., J. W. E. Rush, J. R. Turk, E. M. Price, and M. H. Laughlin. Short-term exercise training increases Ach-induced relaxation and eNOS protein in porcine pulmonary arteries. J. Appl. Physiol., 90: 1102-1110, 2001.

Schrage, W. G. CR Woodman, and Laughlin MH: Mechanisms of flow and ACh-induced dilation in rat soleus arterioles are altered by hindlimb unweighting. J. Appl. Physiol., 92:901-911, 2002.

Aaker, A. and Laughlin M. H. Diaphragm arterioles are less responsive to a1-adrenergic constriction than gastrocnemius arterioles. J. Appl. Physiol., 92:1808-1816, 2002.

Woodman, C. R., J. R. Turk, James W. E. Rush, and Laughlin M. H. Exercise attenuates the effects of hypercholesterolemia on endothelium-dependent relaxation in coronary arteries from adult female pigs. J. Appl. Physiol., 96:1105-1113, 2004.

Thompson, M. A., K. K. Henderson, C. R. Woodman, J. R. Turk, James W. E. Rush, and M. H. Laughlin. Exercise Preserves Endothelium-Dependent Relaxation in Coronary Arteries of Hypercholesterolemic Male Pigs. J. Appl. Physiol., 96:1114-1126, 2004.

Laughlin M.H. Joseph B. Wolfe Memorial lecture. Physical Activity in Prevention and Treatment of Coronary Disease: The Battle Line is in Exercise Vascular Cell Biology. Med. & Sci. In Sports & Exercise. 36:352-362, 2004.

Graduate Studies in Biomedical Sciences

At the Department of Biomedical Sciences, investigators are engaged in research across a variety of fields, including cancer, neurodegenerative disease, exercise, cardiovascular, gastrointestinal, respiratory and reproductive physiology.

With world-class and award-winning researchers, our graduate program has a great deal to offer.

Find out more.

Faculty Spotlight

Xiangwei (Shaun) Du, PhD

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  • Retired Associate Dean Ronald L. Terjung Passes Away

Contact

Department of Biomedical Sciences
University of Missouri-Columbia
E102 Veterinary Medical Building
1520 Rollins Street
Columbia, MO 65211
Phone: 573-882-7011
Fax: 573-884-6890

 

Administrative Contacts

Dr. Douglas Bowles
Department Chair

BowlesD@missouri.edu
573-882-7193

Dr. Kevin Cummings
Director of Graduate Studies
cummingske@missouri.edu
573-882-0283

Thomas Thompson
Business Manager

ThompsonT@missouri.edu
573-882-4503

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